Cancer Research Pulmonary Toxicology
(Laboratory Animal, Primates)

Metabolic activation and detoxication of environmental chemicals that produce tissue selective cytotoxicity, particularly of the lung.

Mechanisms for cellular degeneration, especially with regard to the role of reactive metabolites.

Metabolic activation and detoxication of environmental chemicals that produce tissue selective cytotoxicity, particularly of the lung.  Mechanisms for cellular degeneration especially with regard to the role of reactive metabolites.  Pharmacokinetics, xenobiotic metabolism, lung toxicity.  Alterations of pulmonary cell homeostasis assessed by micro array and proteomic approaches