PTX 201 Course Outline:
Course Instructor: Alan Buckpitt
Monday-Friday 9-10AM
2016 Haring Hall
TAs Heather Knych and…
Date |
Lecture |
Faculty |
Block I - Overview |
||
Thursday 9/28 |
Introduction/Course Outline. Pharmacology and Toxicology-definitions, subdisciplines and opportunities; literature sources |
Buckpitt |
Friday 9/29 |
Physicochemical properties of drugs and toxicants; Dose Response |
Miller |
Monday, 10/2 |
Risk assessment-Extrapolation of data derived in animals to humans |
Last |
Tuesday, 10/3 |
Fate of chemicals in the environment I |
Tjeerdema |
Wednesday, 10/4 |
Fate of chemicals in the environment II |
Tjeerdema |
Thursday, 10/5 |
Receptors as targets for drugs and toxicants |
Pessah |
Friday 10/6 |
The concept of selectivity. Basic understanding of how drugs and toxicants produce selective therapeutic/toxic responses |
Pessah |
Monday 10/9 |
Drug development |
O’Neill |
Tuesday 10/10 |
Discussion for exam |
Miller/Last/Pessah/Tjeerdema |
Wednesday 10/11 |
Exam I |
TBA |
Block II |
||
Thursday 10/12 |
Fate Processes-I: Absorption |
Buckpitt |
Friday 10/13 |
Fate Processes-II: Distribution |
Buckpitt |
Monday 10/16 |
Fate Processes-III: Metabolism |
Buckpitt |
Tuesday 10/17 |
Fate Processes-IV: Metabolism |
Buckpitt |
Wednesday 10/18 |
Fate Processes-V: Elimination |
Buckpitt |
Thursday 10/19 |
Factors affecting disposition and fate of drugs and toxicants |
Buckpitt |
Friday 10/20 |
Fate Processes in nonmammalian species |
Tjeerdema |
Monday 10/23 |
Pharmacokinetics I |
Miller |
Tuesday 10/24 |
Pharmacokinetics II |
Miller |
Wednesday 10/25 |
Pharmacokinetics III |
Miller |
Thursday 10/26 |
Pharmacokinetics IV Problems and computer analysis |
Craigmill |
Friday 10/27 |
Pharmacokinetics V Problems and computer analysis |
Craigmill |
Monday 10/30 |
Physiologically based pharmacokinetic modeling |
Craigmill |
Tuesday 10/31 |
Pharmacokinetics of reactive metabolite formation and decay |
Miller |
Wednesday 11/1 |
Discussion |
Craigmill, Miller, Tjeerdema, Buckpitt |
Thursday 11/2 |
EXAM Block II |
|
Block III-Target organ toxicity |
||
Friday 11/3 |
Mechanisms of cell injury I. Reactive oxygen species, redox cycling |
Last |
Monday 11/6 |
Cellular basis of toxicity. Intracellular targets, comparisons of the structure and function of cells undergoing apoptosis vs necrosis |
Van Winkle |
Tuesday 11/7 |
Structure and function of the hepatic system |
Wilson |
Wednesday 11/8 |
Hepatotoxicants |
Wilson |
Thursday 11/9 |
Mechanisms of cell injury II: Interactions of reactive metabolites with critical macromolecules |
Miller |
Friday 11/10 |
Veterans day |
|
Monday 11/13 |
Structure and function of the renal system |
Wilson |
Tuesday 11/14 |
Structure and function of the respiratory system |
Van Winkle |
Wednesday 11/15 |
Pulmonary Toxicants I. Chemicals |
Buckpitt |
Thursday 11/16 |
Renal toxicants |
Buckpitt |
Friday 11/17 |
Diuretics |
Buckpitt |
Monday 11/20 |
Pulmonary toxicants I Particles |
Pinkerton |
Tuesday 11/21 |
Discussion |
Pinkerton, |
Wednesday 11/22 |
Exam Block III |
|
Thanksgiving Holiday |
||
Monday 11/27 |
Bacteria: Targets for selective toxicants I and general resistance mechanisms |
Vulliet |
Tuesday 11/28 |
Bacteria as targets for selective toxicants II |
Vulliet |
Wednesday |
Bacteria as targets for selective toxicants III |
Vulliet |
Thurs 11/30 |
Molecular and Cellular Aspects of Cancer |
Cortopassi |
Friday 12/1 |
Strategies in the treatment of Cancer |
Lau |
Monday 12/4 |
Cancer chemotherapy I |
Lau |
Tuesday 12/5 |
Cancer Chemotherapy II |
Lau |
Wednesday 12/6 |
Attempts to selectively target viruses |
North |
Thursday 12/7 |
Discussion Block IV |
Vulliet/Lau/North |
Faculty list: PTX 201
Alan Buckpitt |
2-7674 |
arbuckpitt@ucdavis.edu |
Gino Cortopassi |
4-9341 |
gacortopassi@ucdavis.edu |
Art Craigmill |
2-2936 |
alcraigmill@ucdavis.edu |
Jerold Last |
2-6230 |
jalast@ucdavis.edu |
Derrick Lau |
916-734-3863 |
derrick.lau@ucdmc.ucdavis.edu |
Marion Miller |
4-8982 |
mgmillersears@ucdavis.edu |
Thomas North |
2-3414 |
twnorth@ucdavis.edu |
Charles O’Niell |
Sr Director, BioMarin, Novato |
|
Isaac Pessah |
2-6696 |
inpessah@ucdavis.edu |
Kent Pinkerton |
2-8334 |
kepinkerton@ucdavis.edu |
Ron Tjeerdema |
4-5192 |
rstjeerdema@ucdavis.edu |
Laura Van Winkle |
4-7547 |
lsvanwinkle@ucdavis.edu |
P. Richard Vulliet |
2-7409 |
prvulliet@ucdavis.edu |
Dennis Wilson |
2-0158 |
dwwilson@ucdavis.edu |
