Dr. Genetos’s research focuses upon the mechanisms whereby bone cells respond to biophysical signals present during skeletal development, repair, and daily activity.  Using both in vitro models for mechanical loading and in vivo transgenic or knockout mouse models, current research focuses include 1) the interaction of mechanical and chemical signals upon skeletal homeostasis;  2) diseases involving the skeletal system, including ectopic calcification within the vasculature, or mechanisms of prostate cancer osteosclerosis.