Cardiovascular and Neuro Pharmacology and Toxicology
(Companion Animal, Laboratory Animal)
Mechanisms by which pharmacological agents and toxicants influence biochemical targets at the level of receptors and ion channels,
especially to elucidate structure/function relationships. Cellular,
biochemical and molecular approaches are used. The impact of
xenobiotics or calcium homeostasis at the cellular & subcellular
level; present focus is on ligand gated calcium release channel which
plays a key role in excitation-contraction coupling in muscle cells
and neurotransmitter release in nerve cells.
Molecular and cellular mechanisms regulating cellular Ca2+ signaling. The structure, function, pharmacology of intracellular calcium release channels of sarcoplasmic and endoplasmic reticulum in striated muscle and neurons. Mechanisms by which xenobiotics alter cellular calcium signaling and calcium-dependent processes and its impact on regulation of cell growth and differentiation. Environmental etiology of autism.
